5. Involvement of dietary toxicity and epigenetic mechanisms on gap junction intercellular communication
نویسندگان
چکیده
The ability to communicate is an important feature of multicellularity (Hervé et al., 2005). The coordinated integration of extracellular, intracellular, and intercellular mechanisms promotes the maintenance of homeostasis in higher organisms. Direct intercellular communication is mainly mediated by gap junction channels, which are formed by members of the connexin protein family in vertebrates. Connexins (Cx) are look like plaques that at the cell plasma membrane surface regulate electrical signals and the passage of ions, small biological molecules ( 1000 Da), including sugar, nucleotides, amino acids, second messengers such as Ca2+, cyclic AMP and inositol triphosphate, as well as metabolic precursors, between neighboring cells. Gap junction intercellular communication (GJIC) are critically important in many biological activities, including morphogenesis, cell differentiation, growth
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